Sep 2026 · 9 min
Reference Material Certification: A Canadian Lab Guide
Discover the essentials of reference material certification and learn how it validates certified reference materials in Canadian labs.
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Notes on the leaf, and using it well.
Plain-spoken writing about kratom and 7OH: the science, the responsible-use practices, and the transparency the category usually skips.
21–30 of 52
21 min
Stability Indicating Methods: A Validated Lab Workflow
A stability-indicating method (SIM) is a validated quantitative analytical procedure that accurately measures active pharmaceutical ingredient (API) concentration over time without…
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12 min
Mitragynine vs 7-Hydroxymitragynine: What Canadian Labs Need to Know
7-hydroxymitragynine (7-OH) is the higher-potency μ-opioid receptor (MOR) ligand of the two kratom alkaloids, with roughly 99-fold lower Ki than mitragynine in human MOR binding assays, and…
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12 min
MGM-15 vs 7-OH: A Scientific Pharmacological Comparison
How do MGM-15 and 7-OH differ pharmacologically? MGM-15 and 7-hydroxymitragynine (7-OH) are both kratom-derived opioid alkaloids, but they occupy meaningfully different positions on the…
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11 min
MGM-15 for U.S. Labs: Research-Grade Sourcing Guide
MGM-15, formally known as dihydro-7-hydroxymitragynine (DH-7OH-MIT), is a semi-synthetic opioid analogue of 7-hydroxymitragynine, that U.S. laboratories should source only from a compliant…
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18 min
Dissolution Testing Tablets for Analytical Labs: 2026 Guide
For U.S. analytical labs working with 7-hydroxymitragynine (7OH), the recommended approach is to order both tablet and powder forms, then verify every shipment against a batch-specific…
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10 min
7OH vs 7-Hydroxymitragynine: Potency, Risks, and Canadian Law
7OH and 7-hydroxymitragynine are the same chemical compound. “7OH” is simply the shorthand that researchers, clinicians, and product marketers use for 7-hydroxymitragynine, a terpenoid…
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7 min
Reference Material Traceability for Canadian Labs: 2026 Guide
What is reference material traceability, and why does it matter? Metrological traceability is the property of a measurement result whereby it can be related to a reference through a…
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11 min
7-Hydroxymitragynine Purity Levels for Analytical Labs
For research-grade 7-hydroxymitragynine reference materials, request a high-purity assay (mass fraction, dry basis) assigned by a validated HPLC or UPLC method, with a lot-specific…
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7 min
Temperature Controlled Shipping Canada for Research Labs
Shipping research-grade 7-hydroxymitragynine and related alkaloids across Canada requires a validated cold-chain workflow: an engineered packout paired with a calibrated data logger, a…
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12 min
Mitragynine Pseudoindoxyl vs 7OH: Lab Research Guide
Mitragynine pseudoindoxyl (MP) is the more potent mu-opioid agonist of the two: the CFSRE monograph reports a Ki of 1.5 nM for MP versus 78 nM for 7-hydroxymitragynine (7OH), and an ED50 of…
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New drops and the occasional well-researched note. No spam.
